Ependymomas are a type of brain tumor that is notoriously difficult to treat. Scientists with the SU2C-St. Baldrick’s Foundation Pediatric Cancer Dream Team mapped out the genetic landscape of selected ependymomas to find targets for treatment and reported encouraging preliminary data on the identification of drugs that could have an impact on the tumors. Their report, with Michael D. Taylor, MD, PhD, a principal investigator with the Dream Team, as a senior author, is published in Nature, the highest-ranked journal of general and multidisciplinary science in the world. Our colleagues at the American Association for Cancer Research have prepared the attached Science Update on the paper, discussing its importance in the quest to find treatments for these tumors that occur most often in infants and children.