April 3, 2017 – WASHINGTON – Stand Up To Cancer (SU2C) announced today the formation of a “Dream Team” of top researchers to take on one of the toughest challenges in cancer research and treatment: colorectal cancer, which is expected to claim the lives of more than 50,000 Americans this year. The announcement was made at a special event during the 2017 Annual Meeting of the American Association for Cancer Research (AACR), SU2C’s Scientific Partner.
“We are urgently in need of new approaches to colorectal cancer,” said Phillip A. Sharp, PhD, institute professor at MIT’s Koch Institute for Integrative Cancer Research, Nobel Laureate, and chairman of SU2C’s Scientific Advisory Committee. “We have made great progress in prevention through widespread screening, but new methods are needed to treat colorectal cancer when it actually occurs.”
The SU2C Colorectal Cancer Dream Team, with funding of up to $12 million from SU2C, will be led by Luis A. Diaz, MD, of Memorial Sloan Kettering Cancer Center in New York, as leader, and Charles S. Fuchs, MD, MPH, director of the Yale Cancer Center in New Haven, Connecticut; Lewis Cantley, PhD, director of the Meyer Cancer Center at Weill Cornell Medicine and NewYork-Presbyterian Hospital in New York; and Zhenghe Wang, PhD, of the School of Medicine at Case Western Reserve University in Cleveland, as co-leaders. More than 50 researchers at six institutions are involved in the team.
“I know first-hand how devastating a colon cancer diagnosis can be,” said Katie Couric, the journalist who is a co-founder of SU2C and whose first husband, Jay Monahan, died of colorectal cancer in 1998, after a nine-month battle with the disease. “After Jay was diagnosed, I was shocked to learn that the first-line treatment for those with advanced disease hadn’t changed much since the 1950s. Today there are more therapeutic options, but colorectal cancer is still the second-leading cancer killer of men and women combined in this country. I am enormously pleased and proud that SU2C is bringing a team of talented scientists who will be empowered to do all they can to fight this insidious killer.”
“Through a combination of new avenues in immunotherapy, targeted therapeutics, metabolomics, and precision prevention, we believe we can find new ways to fight colorectal cancer and bring new hope to patients,” Diaz said.
The team’s research program will also include clinical trials to investigate drugs that could attack genetic vulnerabilities in many types of colorectal cancer tumors.
“The metabolism of cancer cells, how they process nutrients, is different from normal cells,” Cantley said. “The trials are designed to take advantage of that knowledge and hopefully kill the cells.”
Serving as Dream Team Principals are Ryan B. Corcoran, MD, PhD, Massachusetts General Hospital Cancer Center, and Nilofer S. Azad, MD, Johns Hopkins University. Serving as Dream Team Advocates are Anjee Davis, president, Fight Colorectal Cancer; Ivelisse M. Page, executive director and co-founder, Believe Big, Inc.; Joanna Fuchs, MD, patient advocate, Yale University; Martha Raymond, executive director, Michael’s Mission; Thomas Herbert Marsilje; and Vanessa L. Whiting, president, A.E.S. Management Corp.
In this United States this year, an estimated 135,430 people will be diagnosed with colorectal cancer and about 50,260 people will die from it, according to the American Cancer Society; and one in 22 men and one in 24 women will be diagnosed with colorectal cancer in their lifetimes.
Of cancers that affect both men and women, colorectal cancer is the second leading cause of cancer-related deaths in the United States and the third most common cancer in men and in women, according to the Centers for Disease Control and Prevention.
The colorectal team is the 20th Dream Team launched by Stand Up To Cancer since its inception in 2008, which has also launched six Translational Research Teams, 46 Innovative Research Grants, and a host of other grants and awards to encourage innovative and collaborative cancer research, with funds committed by philanthropic, organizational, corporate, and individual donors, as well as nonprofit groups working with SU2C.
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Richard L. Lobb
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About the Stand Up To Cancer Initiative
Stand Up To Cancer (SU2C) raises funds to accelerate the pace of research to get new therapies to patients quickly and save lives now. SU2C, a program of the Entertainment Industry Foundation (EIF), a 501(c)(3) charitable organization, was established in 2008 by film and media leaders who utilize the industry’s resources to engage the public in supporting a new, collaborative model of cancer research, and to increase awareness about cancer prevention as well as progress being made in the fight against the disease. As SU2C’s scientific partner, the American Association for Cancer Research (AACR) and a Scientific Advisory Committee led by Nobel Laureate Phillip A. Sharp, PhD, conduct rigorous, competitive review processes to identify the best research proposals to recommend for funding, oversee grants administration, and provide expert review of research progress.
Current members of the SU2C Council of Founders and Advisors (CFA) include Katie Couric, Sherry Lansing, Lisa Paulsen, Rusty Robertson, Sue Schwartz, Pamela Oas Williams, Ellen Ziffren, and Kathleen Lobb. Noreen Fraser and the late Laura Ziskin are also co-founders. Sung Poblete, Ph.D., R.N., has served as SU2C’s president since 2011.
For more information on Stand Up To Cancer, visit www.standup2cancer.org.
About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world’s first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 36,000 laboratory, translational, and clinical researchers; population scientists; other health care professionals; and patient advocates residing in 107 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis, and treatment of cancer by annually convening more than 30 conferences and educational workshops, the largest of which is the AACR Annual Meeting with nearly 19,500 attendees. In addition, the AACR publishes eight prestigious, peer-reviewed scientific journals and a magazine for cancer survivors, patients, and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration, and scientific oversight of team science and individual investigator grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and other policymakers about the value of cancer research and related biomedical science in saving lives from cancer. For more information about the AACR, visit www.AACR.org.