T-Cell Lymphoma Dream Team - Stand Up To Cancer

Dream Teams

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SU2C Meg Vosburg T-cell Lymphoma Dream Team:
Tailoring CAR-based Immunotherapy Strategies
to T-cell Lymphoma

Grant Term: January 2019 – December 2021

The goal of this team is to develop an effective treatment for T-cell lymphoma, a rare cancer of the blood and immune system for which few therapeutic options currently exist. The team is using powerful new immunotherapy approaches to both destroy T cells that have become malignant and prepare patients, when indicated, for successful stem cell transplants to contain or cure the cancer. By conducting clinical trials, the team hopes to create durable responses with therapies that can be applied to a wide variety of T-cell lymphoma malignancies.


Cancer immunotherapy—enabling the body’s immune system to detect and destroy cancer cells—has had a tremendous impact on a wide range of cancers, including B-cell lymphomas. However, it has not yet been effective in those lymphomas that originate primarily from T cells. The scientific challenge is in finding a therapy that can attack the cancerous T cells while leaving normal cells intact, since T cells are essential to the body’s immune system.

The SU2C Meg Vosburg T-cell Lymphoma Dream Team is testing engineered cells that carry molecules known as chimeric antigen receptors, or CARs, which can lock onto proteins on the surface of cancerous T cells and destroy them. Finding the best combination of CARs and engineered cell types is a key goal of the Dream Team. In addition, the team is working to modify the CAR-carrying cells so that they are not hindered by immune cells. This will help reduce the cancer and prepare patients for potential stem cell transplants to contain or cure the cancer. CAR therapy is usually custom-built for each patient. The team is trying to find a way to develop CAR cells on an “off-the-shelf” basis so the therapy will be more available to patients and less expensive.

This team is named in honor of Mary Margaret (Meg) Moretti Vosburg, a lifelong learner, educator and humanitarian, who died on May 26, 2018, after a hard-fought battle with lymphoma at the age of 51.


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