Pancreatic cancer cells have a high level of a protein, called TGF-β, that can repress the activity of the immune system in fighting cancers. This research team can isolate tumor-specific killer T cells (called tumor-infiltrating lymphocytes, or TILs) from pancreatic cancer tissue and transfer them back to the patient for maximal impact against the tumor cells. The team is engineering TIL to make the cells resistant to the suppressive effect of TGF-β, potentially enabling the TIL to attack the cancer tissue within the pancreas.
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